文档介绍：IgA肾病与过敏性紫癜性肾炎的临床和病理对比分析
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作者:周长华蔡林祥朱月文居建析徐宏
【摘要】目的对比研究有新月体形成(50%)的IgAN肾病(IgAN)和过敏性紫癜性肾炎(HSPN)在临床及肾脏病理改变上的异同,探讨两者的关系。方法对经肾活检证实的病理上有50%新月体形成的25例IgAN及23例HSPN***(18岁)进行临床及病理对比分析。结果 IgAN和HSPN临床表现相似,高血压、血尿、蛋白尿、尿NAG酶升高等发生率差异均无显著性();IgAN肾功能损害程度较重,两者的血肌酐水平差异有显著性();IgAN和HSPN肾脏的组织病理检查,节段新月体形成率和球囊粘连、内皮增生、节段硬化等发生率差异均无显著性(),而袢坏死、球性硬化、肾间质纤维化、肾小管萎缩发生率差异均有显著性();两组免疫病理均以IgA在系膜区沉积为主(伴或不伴血管袢的沉积),沉积差异无显著性()。结论 IgAN与HSPN两者在高血压、血尿、蛋白尿发生率等临床表现差异无显著性,但IgAN肾功能减退明显,肾组织发生球性硬化、间质纤维化、小管萎缩等慢性化病变较重。
【关键词】 IgA肾病过敏性紫癜性肾炎新月体临床和病理
【Abstract】 Objective pare the clinical and pathological charactersistics in patients with crescentic(50%)IgA nephropathy(IgAN) and Henoch-Schonlein purpur
a nephritis(HSPN). The present study aimed to characterize their relationship through parison between IgAN and HSPN. Methods 25 adult with IgAN and 23 adult with HSPN in this study. Their clinical manifestations,blood biochemical test , renal pathological findings in light microscopy and immunofluorescence were analyzed and pared between 25 IgAN and 23 HSPN . Result The clinical patterns of IgAN and HSPN were similar. Hypertension/ hematuria(severe and mirror) / proteinuria and urine NAG enzymatic arising were not significant ().But in IgAN ,renal function was damaged badly and the serum creatinine was significantly higher than that in HSPN (). Pat