文档介绍：
免疫球蛋白受体作为药物靶点的研究进展#
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(1. 安徽医科大学临床药理研究所,合肥 230032;
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2. 安徽医科大学临床药理研究所,合肥 230032)
摘要:免疫球蛋白(Immunoglobulin, Ig)又称为抗体,是体内体液免疫的重要组成部分。Ig 与免疫球蛋白
受体(immunoglobulin receptor, IgR)结合触发相应的生物学活性。不同的 Ig 亚型有不同的生物学功能,
且 IgR 可作为炎症免疫相关疾病的治疗靶点,本文综述了 IgR 功能及在炎症免疫相关疾病治疗与药物研究
中的作用。
关键词:免疫球蛋白受体;功能;炎症;治疗
中图分类号:R967 免疫药理学
Progress in the study of a new therapeutic target:
immunoglobulin receptors
HUANG Qiong1, CHEN Wensheng2, WU Yujing2, WEI Wei2
(1. Institute of Clinical Pharmacology, Anhui Medical University,Hefei, . China 230032;
2. Institute of Clinical Pharmacology, Anhui Medical University, Hefei, . China 230032)
Abstract: Immunoglobulins (Ig), also called antibodies, are ponents in
humoral-mediated immunity. Ig can bind with their receptors, called immunoglobulin receptors
(IgR), trigger biologic activity respectively. Different subtypes of Igs show different function. And
IgRs have been treated as therapeutic targets in inflammation and immunity related diseases for
many years. This article reviewed the recent progresses in the study of IgR function and its
therapeutic role in inflammation and immunity related diseases.
Key words: immunoglobulin receptor; function; inflammation; therapy
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0 引言
免疫球蛋白(Immunoglobulin, Ig)是一类具有抗体活性或化学结构与抗体相似的球蛋白。
Ig 或抗体是体内体液免疫的重要组成部分。Ig 是由两条相同的轻链和重链组成的异源性四
聚体,根据 Ig 重链不同将其分为 5 类:IgG (γ链)、 IgE (ε链)、IgA (α链)、