文档介绍：摘要本论文是关于医药中间体2,3,4,。以四氯邻苯二甲酸为原料分别经酰亚胺路线(包括酰亚胺化、氟化、水解、脱羧四步反应)及经酰氯化路线(包括水解、酰氯化、氟化、水解、脱羧五步反应)合成了2,3,4,。:再以杯芳烃A为催化剂,环丁砜为溶剂,:以硫酸为溶剂,以十二烷基苯磺酸钠为催化剂合成四氟邻苯二甲酸;再以三正丁基胺为溶剂脱羧得到2,3,4,,%。经酰氯化路线同样是以四氯邻苯二甲酸酐为原料,在氢氧化钠溶液中碱溶后在盐酸中酸析合成四氯邻苯二甲酸;再以DMF为催化剂与二氯亚砜反应生成四氯邻苯二甲酰氯;以杯芳烃A为催化剂,环丁砜为溶剂,氟化钾为氟化剂进行置换氟化反应,再用碳酸氢钾溶液水解合成四氟邻苯二甲酸;以三正丁基胺为溶剂脱羧得到2,3,4,,%。关键词:2,3,4,5-,3,4,5-tetrafluorobenzoicacid,(includeimidization,fluorination,hydrolyzationanddecarboxylafion4steps)andacylchloride(includehydrolyzation,acylchlorination,fluorination,hydrolyzationanddecarboxylation5steps)—,N—phenyltetrafluoridephthalimidewasobtainedfromN-,-H-%.Samelyintheacylchlorideroute,tetrachloridephthalicanhydrideWaSaddedintothesolventofsodiumhydroxideandthenintothehydrochloricacidtoproducetetrachloridephthalicacid;thenreactedwiththionychlorideunderthecatalysisofDMFtoformtetrachloridephthaloylchloride;withpotassiumfluorideasthefluridizer,calixareneAaSthecatalysis,ogivetheproductfromtetrachioridephⅪnaloylchlorideandthentheproductWasaddedintothesolventofpotassiumbicarbonatetobehydrolyzatedtosynthe