文档介绍：Carbon Nanopowder Binds with DNA and May
Induce DNA Aggregation
Changlu Guo1,3†, Qingdai Liu2†, Qiaoli Ji2†, Hongjie An2, Zhizhou Zhang1,2,3*, Yadong Wang1,3
1Research Center of Bioinformation Technology,School puter Science and Technology, Harbin Institute of Technology, Harbin, China 150001
2Bio-X center, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology
3Bio-X Center for Marine Biotechnology, Harbin Institute of Technology, Weihai, China 264209
†Equal contribution; *Contact: zhangzzbiox@, ******@hit.
Abstract—The interaction between nanomaterials and genomes is rat model. Moreover, evidences of human cell response to
getting more and more attention. Such studies are getting carbon nanoparticles showed lipid membrane peroxidation,
involved into several fields: environment safety, food safety, down-regulation of genes encoding adhesive proteins, and
nanobiotechnology and drug development. Direct interaction increased cell death including necrosis and apoptosis [13].
between nanoparticles and DNA in vitro has been reported in
several studies, but data for in vivo binding between genomic For fundamental understanding the impact of carbon
DNA and nanoparticles are rare. In this study, we presented that nanoparticles on ics and what the limit should be set in
carbon nanopowder (CNP) is able to bin