文档介绍：Effect of oxygen level on efficiencies of metabolic
fluxes in Klebsiella pneumoniae
Qingrui Zhang, Weiwen Wang, Hua Xiao Zhilong Xiu
College of Chemical Engineering, Department of Bioscience & Biotechnology,
Qingdao University of Science and Technology, Dalian University of Technology
Qingdao 266042, PR China Dalian 116023, PR China
******@qust. E-mail address: ******@dlut.
Abstract—Control-effective flux(CEF) analysis is a useful tool in estimation of gene expression changes[9-11]. Cakir et al.
assessing a metabolism. In this work, a model that utilizes studied the influences of enzyme-deficient in erythrocyte
existing knowledge of oxygen and redox sensing/regulatory metabolism using this method[12].
system to assist elementary flux modes (EFMs), has been
developed and CEF analysis was performed to analyze the In this work, CEF analysis was performed to analyze the
influence of oxygen level on the transcriptional regulation in influence of oxygen level on the transcriptional regulation in K.
Klebsiella pneumoniae. It was found that the efficiency of pneumoniae and the activities of pathways upon different
reductive pathway was higher than oxidative pathway under oxygen level pared with emphasis.
anaerobic condition and reversed under aerobic condition.
During the transition from anaerobic to aerobic conditions, the
efficien