文档介绍：1 药物性肝病 82 例临床分析作者:陈建婷,严喜章,陈观发,苗继延【摘要】目的: 分析诱发药物性肝病的药物种类、临床特点及提高对药物性肝病的认识。方法:对 82 例药物性肝病病例进行回顾性分析, 数据用 Excel 进行统计处理。结果: 致肝损害药物以抗结核药物最常见,占 %(27/82), 其次为抗生素,占 %(11/82); 临床表现以黄疸最多见,占 %(37/82), 轻微肝病症状的占 %(40/82) 。结论: 药物性肝病可由多种药物引起, 起病隐匿, 肝功能检查是早期诊断的主要方法, 早期及时停用损肝药物是治疗的关键。【关键词】药物性肝病; 抗结核药; 黄疸 Clinical Analysis of 82 Cases of Drug Induced Liver Diseases Abstract: Objective To analyze the etiology ,clinical characteristics and improve the understanding of drug induced liver disease. Methods Retrospective method was adopted in the study and the data were processed by use of Excel. Results 2 The mon agent to induce liver disease was antitubercular drug ( %) ,the second was antibiotics ( %) . Jaundice ,the mon symptom ,occurred to 37 cases ,and slight symptom related to liver disease occurred to 40 cases. Conclusion Almost all agents used in clinic may cause liver disease. Clinical feature of the drug induced disease may be latent ,the major means for its early detection is liver function test such as ALT. The principal management for the disease is discontinuation of the suspected drugs. Key words: Drug induced liver disease; Antitubercular drug; Jaundice 随着医药工业的迅猛发展, 新药大批涌现, 药物性肝病也有所增加, 本文收集了我院近 9 年住院的药物性肝病患者 82 例,对诱发药物性肝病的药物种类、临床表现和预后进行分析, 以提高临床医师对该病的认识, 使该病能得到早期诊断和及时治疗。 1 对象和方法对象 3 1997 年1月至 2006 年11 月在本院住院的药物性肝病患者共 82例, 其中男性 49例, 女性 33例。年龄 12 岁~ 83岁, 平均年