文档介绍：新疆医科大学
硕士学位论文
妊娠期肝内胆汁淤积症肝功能变化与围产儿预后的研究
姓名:玛依姑丽·阿木提
申请学位级别:硕士
专业:妇产科学
指导教师:王冬梅
2009-04
摘要
妊娠期肝内胆汁淤积症肝功能变化与围产儿预后的研究
研究生::王冬梅
摘要
目的:通过 ICP(妊娠期肝内胆汁淤积症)患者生化指标的改变及妊娠结局的分
析,探讨其对胎儿预后影响的重要性。方法:对 2005 年 1 月~2008 年 6 月在我院终
止妊娠的 ICP 患者的谷丙转氨酶、谷草转氨酶及甘胆酸水平等生化指标与胎儿预后
(包括:胎膜早破、胎儿宫内窘迫、早产、死产、死胎、羊水过少、羊水污染、新
生儿窒息及新生儿黄疸等)进行分析。结果:ICP 患者的众多不良妊娠结局中,早产、
死产、羊水污染及新生儿黄疸与甘胆酸水平的高低有相关性;早产及新生儿黄疸与
转氨酶水平的高低有相关性;胎心电子监护则只能反映胎儿在宫内是否存在缺氧及
有无潜在黄疸,与 ICP 的其他众多不良妊娠结局无相关性。结论:ICP 是一种由于大
量胆汁酸淤积于胎盘血管引起的疾病,母体高浓度的胆汁酸水平可导致胎儿严重并
发症。
关键词:ICP;转氨酶;甘胆酸;胎儿预后
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新疆医科大学医学硕士学位论文
The research of liver function and fetus prognosis of
intrahepatic cholestasis of pregnancy
Postgraduate :Ma Muti Supervisor:Wang Dongmei
Abstract
Objective:The purpose of this study is to be explored the influence of ICP
(intrahepatic cholestasis of pregnancy) on the fetal prognosis by biochemical indicator
and analyse the e of pregnancy. Methods:244 patients with ICP in 10153
pregnancy women who delivered their babies in our hospital were enrolled in this study
from January, 2005-June, biochemical indicators were analysed such as alanine
aminotransferase, aspartate aminotransferase, glucocholic acid (CG) and the fetal
prognosis (including: premature rupture of membranes, fetal distress , premature birth,
stillbirth, stillbirth, oligohydramnios, meconium stained, neonatal asphyxia and neonatal
jaundice, etc.) Results:In many adverse pregnancy es of ICP in patients, the
premature, meconium stained and neonatal asphyxia were related to the level of CG;
preterm labor and neonatal asphyxia were related to increaseing transaminase level. The
electronic fetal monitoring can only reflect the existence of the fetus hypoxia, but its can
not reflect other adverse pregnancy :there were the relationship
between the changes of increaseing transaminase level, glycocholic acid and the advers